WHO Tumor Classification (5th edition)

WHO Classification of Tumours Editorial Board. Breast tumours [Internet]. Lyon (France): International Agency for Research on Cancer; 2019. (WHO classification of tumours series, 5th ed.; vol. 2). Available from: https://tumourclassification.iarc.who.int/chapters/32.

https://www.youtube.com/watch?v=gyyFjJFnKdY

Epithelial tumours of the breast

Fibroepithelial tumours and hamartomas of the breast

Tumours of the nipple

Mesenchymal tumours of the breast

Haematolymphoid tumours of the breast

Tumours of the male breast

Genetic tumour syndromes of the breast

Radiology

US Imaging

Tsukuba university score: https://doi.org/10.1148/radiol.2391041676

Score	Classification standard
SC1	Uniform strain throughout the entire hypoechoic area–similar to the surrounding tissue (most green)
	3 layered RGB colour pattern, RED located at the posterior part–typical artifact pattern seen in a cyst
SC2	Strain throughout the most of the hypoechoic area with some areas spared (mainly green with some blue spots)
SC3	Strain at the periphery of the nodule, no strain in the centre (centre blue and peripheral part of the nodule green)
SC4	No strain within the entire hypoechoic area (entire lesion is blue)
SC5	No strain within the hypoechoic area nor in the surrounding tissues (lesion is blue outside rim also blue)

BGR sign (blue-green-red-sign): Due to technical reasons, liquid cysts are regularly associated with the BGR-sign, a color pattern with blue in the top area of the lesion, green in the middle and red at the bottom that particularly applies to the Hitachi system) or with a color distribution resembling a “bull’s-eye” (which particularly applies to the Siemens system). Lesions displaying these color distributions are defined as probably benign, as this phenomenon is regularly and exclusively observed in cysts

![Tsukuba Elasticity Score (TES). Schematic view, sonoelastography and B-mode ultrasound of lesions categorized as TES 1–5 or BGR-sign.

Wojcinski, S., Boehme, E., Farrokh, A. et al. Ultrasound real-time elastography can predict malignancy in BI-RADS®-US 3 lesions. BMC Cancer 13, 159 (2013). https://doi.org/10.1186/1471-2407-13-159](https://prod-files-secure.s3.us-west-2.amazonaws.com/2aa05644-4658-4c26-84d3-64c36b55fb6c/85c237d1-af73-4942-8bc7-32b0adc07f98/12885_2012_Article_3778_Fig1_HTML.webp)

Tsukuba Elasticity Score (TES). Schematic view, sonoelastography and B-mode ultrasound of lesions categorized as TES 1–5 or BGR-sign.